Gene machine : the race to decipher the secrets of the ribosome / Venki Ramakrishnan.

By:

Ramakrishnan, Venki, 1952-

Language: English Publication details: Uttar Pradesh : Harper Collins Publishers, 2018.Description: xii, 271 p. : ill. ; 25 cmISBN:

9789353023232

Subject(s):

DDC classification:

23 572.8 RAM

Contents:

ch. 1 An Unexpected Change of Plans in America ch. 2 Stumbling into the Ribosome ch. 3 Seeing the Invisible ch. 4 The First Crystals of the Machine ch. 5 Going to the Mecca of Crystallography ch. 6 Emerging from the Primordial Mist ch. 7 A Threshold Is Crossed ch. 8 The Race Begins ch. 9 Getting Started in Utah ch. 10 A Return to Mecca ch. 11 Coming Out of the Closet ch. 12 Almost Missing the Boat ch. 13 The Final Assault ch. 14 Seeing the New Continent ch. 15 The Politics of Recognition ch. 16 The Ribosome Road Show ch. 17 The Movie Emerges ch. 18 The Phone Call in October ch. 19 A Week in Stockholm ch. 20 Science Marches On. Foreword / J.A. Doudna Prologue An unexpected change of plans in America Stumbling into the ribosome Seeing the invisible The first crystals of the machine Going to the mecca of crystallography Emerging from the primordial mist A threshold is crossed The race begins Getting started in Utah A return to mecca Coming out of the closet Almost missing the boat The final assault Seeing the new continent The politics of recognition The ribosome road show The movie emerges The phone call in October A week in Stockholm Science marches on Epilogue.

Summary: "The co-recipient of the 2009 Nobel Prize in Chemistry discusses his critical research on the ribosome, a molecular machine that actually forces DNA into action, turning genetic code into functioning proteins that create life."-- "Everyone has heard of DNA--the molecule that seems to hold the secrets to all life. But by itself, DNA is little more than a blueprint for life, resting inertly within our cells. Hardly anyone, however, has heard of a ribosome. Ribosomes are enormous molecular machines, even more ancient than DNA, that translate the information in our genes into proteins. Those proteins in turn make up much of our bodies and catalyze thousands of processes within our cells. A ribosome, in short, is a machine no cell can do without. And until quite recently, how that machine worked was a mystery. [This book] is an insider account of the Nobel Prize--winning race to uncover the structure of this elusive molecule, told in two interlocking stories. One is a quest of fundamental biology to decipher the structure of the ribosome and show how it functions. This is no idle quest: the ribosome is the target of many major antibiotics, and its structure promises new treatments against deadly infections. The other story is the personal one, a portrait of scientists as human beings, driven as much by rivalry as by the desire to uncover nature's secrets. Ultimately, Gene Machine shows not just what it takes to win a Nobel Prize, but also reveals that who you know and how you handle them are just as important to scientific success as are brains, luck, and hard work. As riveting as it is refreshingly honest, Gene Machine is a story of ambition, achievement, and human frailty in pursuit of high-stakes science."

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Holdings
Item type	Current library	Home library	Call number	Status	Date due	Barcode
AIT-BE Special Collections	Acharya Institute of Technology	Acharya Institute of Technology		Available		31225

Includes bibliographical references.

ch. 1 An Unexpected Change of Plans in America
ch. 2 Stumbling into the Ribosome
ch. 3 Seeing the Invisible
ch. 4 The First Crystals of the Machine
ch. 5 Going to the Mecca of Crystallography
ch. 6 Emerging from the Primordial Mist
ch. 7 A Threshold Is Crossed
ch. 8 The Race Begins
ch. 9 Getting Started in Utah
ch. 10 A Return to Mecca
ch. 11 Coming Out of the Closet
ch. 12 Almost Missing the Boat
ch. 13 The Final Assault
ch. 14 Seeing the New Continent
ch. 15 The Politics of Recognition
ch. 16 The Ribosome Road Show
ch. 17 The Movie Emerges
ch. 18 The Phone Call in October
ch. 19 A Week in Stockholm
ch. 20 Science Marches On.
Foreword / J.A. Doudna
Prologue
An unexpected change of plans in America
Stumbling into the ribosome
Seeing the invisible
The first crystals of the machine
Going to the mecca of crystallography
Emerging from the primordial mist
A threshold is crossed
The race begins
Getting started in Utah
A return to mecca
Coming out of the closet
Almost missing the boat
The final assault
Seeing the new continent
The politics of recognition
The ribosome road show
The movie emerges
The phone call in October
A week in Stockholm
Science marches on
Epilogue.

"The co-recipient of the 2009 Nobel Prize in Chemistry discusses his critical research on the ribosome, a molecular machine that actually forces DNA into action, turning genetic code into functioning proteins that create life."--
"Everyone has heard of DNA--the molecule that seems to hold the secrets to all life. But by itself, DNA is little more than a blueprint for life, resting inertly within our cells. Hardly anyone, however, has heard of a ribosome. Ribosomes are enormous molecular machines, even more ancient than DNA, that translate the information in our genes into proteins. Those proteins in turn make up much of our bodies and catalyze thousands of processes within our cells. A ribosome, in short, is a machine no cell can do without. And until quite recently, how that machine worked was a mystery. [This book] is an insider account of the Nobel Prize--winning race to uncover the structure of this elusive molecule, told in two interlocking stories. One is a quest of fundamental biology to decipher the structure of the ribosome and show how it functions. This is no idle quest: the ribosome is the target of many major antibiotics, and its structure promises new treatments against deadly infections. The other story is the personal one, a portrait of scientists as human beings, driven as much by rivalry as by the desire to uncover nature's secrets. Ultimately, Gene Machine shows not just what it takes to win a Nobel Prize, but also reveals that who you know and how you handle them are just as important to scientific success as are brains, luck, and hard work. As riveting as it is refreshingly honest, Gene Machine is a story of ambition, achievement, and human frailty in pursuit of high-stakes science."

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Gene machine : the race to decipher the secrets of the ribosome /​ Venki Ramakrishnan.

Gene machine : the race to decipher the secrets of the ribosome / Venki Ramakrishnan.