Please use this identifier to cite or link to this item: http://13.232.72.61:8080/jspui/handle/123456789/6545
Full metadata record
DC FieldValueLanguage
dc.contributor.authorVizhi, S Kayal-
dc.contributor.authorShivanand, Kalyanappa-
dc.date.accessioned2023-02-08T05:20:19Z-
dc.date.available2023-02-08T05:20:19Z-
dc.date.issued2010-05-
dc.identifier.citationVizhi, S Kayal;Shivanand, Kalyanappa; Orodispersible tablets; Sumatriptan succinate; Superdisintegrants.;Formulation and evaluation of orodispersible tablets for antimigraine therapy;http://lrc.acharyainstitutes.in:8080/jspui/handle/123456789/6354en_US
dc.identifier.urihttp://13.232.72.61:8080/jspui/handle/123456789/6545-
dc.descriptionDissertationen_US
dc.description.abstractSumatriptan succinate is a selective 5-HT1B/1D receptor agonist and is used in the treatment of acute migraine attacks. Even though Sumatriptan succinate is rapidly absorbed after oral dosing, but has incomplete absorption due to first pass metabolism leading to a reduced oral bioavailability of the drug (14%). Hence, the present investigation is concerned with the development of orodispersible tablets to enhance oral bioavailability. The various superdisintegrants used in the present study were crospovidone, sodium starch glycolate and croscarmellose sodium alone and in combinations in three different ratios. Various formulations of orodispersible tablets were prepared by direct compression method. The prepared orodispersible tablets were evaluated for various physical parameters, wetting time, in vitro disintegration time and in vitro drug release. The most satisfactory formulation showed minimum disintegration time of 17 s and released maximum amount of drug in shortest duration of time in 5 min. It was found to be stable during stability studies conducted for 2 months as per ICH guidelines.en_US
dc.language.isoenen_US
dc.publisherAcharya & BM Reddy College of Pharmacy (ABMRCP)en_US
dc.subjectOrodispersible tablets; Sumatriptan succinate; Superdisintegrants.en_US
dc.titleFormulation and evaluation of orodispersible tablets for antimigraine therapen_US
dc.typeThesisen_US
Appears in Collections:Dissertations

Files in This Item:
File Description SizeFormat 
04. ABSTRACT.pdfAbstract261.91 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.