Synthesis and Biological Activity of Substituted Chalcone Derivatives

Abstract

Various heterocyclic compounds possess wide range of biological and pharmacological activities. Among a wide variety of heterocycles that have been explored for developing pharmaceutically important molecules such as Chalcones and Pyrimidines have played an important role in the area of medicinal chemistry. A new series of chalcones were prepared by reacting acetylated 4-amino 1, 2, 4-triazoles and 2-amino 1, 3-thiazole by condensing with various substituted aromatic aldehydes in presence of 70% NaOH as a base. The resultant chalcones undergo cyclization with thiourea in presence of alcoholic KOH to yield pyrimidine derivatives. The structures of the final synthesized compounds were confirmed by IR, MASS & 1H NMR spectra. The newly synthesized compounds were screened for their antimicrobial and antifungal activities. Some of the synthesized compounds showed very good antimicrobial and moderate antifungal activities.