To evaluate the Antipyretic Activity of Prosopis Juliflora Ethanolic extract in Brewer’s yeast induced Hyperthermia in RATS

Abstract

The ethanolic extract of Prosopis juliflora has been explored as potential, effective and safer anti-pyretic activity. A plant which is rich in Alkaloids, Flavonoids, Tannins, Anthraquinones and Quinones and are responsible for inhibition of H+ , K+ ATPase and inhibition of Helicobacter pylori growth. Twenty four male rats were randomly allotted to four groups (6 animals per group) and food was deprived off for 48 hours water provided but before 24 hours of experiment, water also withheld. Group 1 was treated with water for injection (100ml/kg). Group 2 treated with Paracetamol (150 mg/kg p.o dissolved in water for injection). Group 3 and 4 were treated with ethanol extract of Prosopis juliflora (250 and 300 mg/kg p.o respectively). Temperature maintained at ±3°C, for 0 to 4 hours of interval at the dose of 250mg/kg. Significantly reduced the rectal temperature at 3 hours and at dose 500 mg/kg. Significantly reduced the rectal temperature at 2, 3 and 4 hours in comparison with vehicle control. Key words: Antipyretic, Prosopis juliflora, Ethanol extract, Paracetamol